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The Last of Us is HBOs latest mega-popular series. It presents a compelling case that perhaps there’s such a thing as a realistic zombie. Or realistic-ish. And it’s definitely scary.

The premise of the show, which is based on the popular video game of the same name, isn’t that different from your typical post-apocalyptic horror story: US cities are crumbling, there are infectious humans everywhere, and a manly man (played by Pedro Pascal) has to protect a young girl (Bella Ramsay) as they travel across the country.

In the show, it’s not a virus that turns people into zombies but a kind of fungus called cordyceps. The fungus takes over the minds and bodies of humans and makes them want to spread the fungus to the uninfected. The zombie-causing fungus in the show is mostly fictitious — at least, as a human pathogen.

Here’s everything you need to know about the show that has everyone talking — and tweeting.

  • Keren Landman, MD

    Keren Landman, MD

    Why don’t we have vaccines for fungal infections?

    An image from the HBO show, The Last Of Us, showing a person with a fungal rot emerging from their head.
    An image from the HBO show, The Last Of Us, showing a person with a fungal rot emerging from their head.
    An image from the HBO show, The Last Of Us.
    Liane Hentscher/HBO

    The second episode of the HBO hit The Last Of Us opens with a scene in Jakarta, Indonesia. It’s set in 2003, at the beginning of a (fictional) fungal pandemic that goes on to destroy the world as we know it. After an expert in fungal biology evaluates the body of an infected factory worker, she speaks quietly to a military official who has asked for her help controlling the pathogen’s spread.

    “There is no vaccine,” she says to his stricken face.

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  • Oshan Jarow

    Oshan Jarow

    A bioethics professor weighs in on the Last of Us finale

    Joel stands over Ellie who is unconscious on an operating table.
    Joel stands over Ellie who is unconscious on an operating table.
    HBO

    The season finale of HBO’s The Last of Us — based on the video game of the same name — thrust a longstanding philosophical question into the cultural spotlight: Is it ever ethical to kill one person for the well-being of many others?

    If you haven’t seen the show or played the game, a real species of fungus called cordyceps has evolved the ability to inhabit humans, turning them into mushroom-zombies that bite. Twenty years of apocalyptic chaos ensues.

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  • Mac Schwerin

    Prestige TV can’t beat the experience of playing Last of Us

    A man and a teenage girl survey the wreckage of a plane in a field, from afar.
    A man and a teenage girl survey the wreckage of a plane in a field, from afar.
    Joel and Ellie’s relationship is the cornerstone of The Last of Us.
    WarnerMedia

    Prestige TV has finally come for video games. On paper, this is good news. The prestige TV treatment boils down to a rubric of extravagant thoughtfulness — more money for more considered details and more A-list performances — and shows like Severance, Andor, and Succession have served up some of the most gripping and provocative mass-market storytelling as a result.

    So why not be jazzed about HBO’s The Last of Us, right? A beloved video game gets adapted by the only television network most would trust to do it justice. And it looks like great TV. The first several episodes positively sprout with craft. Much of the chatter surrounding the show has evaluated it according to those precepts, creating a kind of circular logic in which it seems self-evident that showrunners Craig Mazin and Neil Druckmann managed to coax a tropey video game premise to its fullest expression.

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  • Alex Abad-Santos

    Alex Abad-Santos

    Pedro Pascal and the unbearable horniness of “daddy”

    A mustached man in glasses and a dark suit sits grinning on the “Tonight Show” set.
    A mustached man in glasses and a dark suit sits grinning on the “Tonight Show” set.
    Pedro Pascal, the daddy of the moment.
    Todd Owyoung/NBC via Getty Images

    At this point, it’s almost impossible to avoid Pedro Pascal. Avoiding him is like evading gravity, unfeasible unless one has access to, say, the moon. The 47-year-old actor is the lead of HBO’s The Last of Us, the biggest show of the moment. In March, he’ll resume his role as the Mandalorian in The Mandalorian, the Star Wars television spinoff that will probably be the biggest show of its moment when the series revs up its third season. Previously, Pascal starred in Narcos and wielded hot bisexual chaos as Oberyn Martel in Game of Thrones.

    Even if you aren’t watching these shows or know nothing about Pedro Pascal, be prepared because he is coming for you, whether you like it or not.

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  • Benji Jones

    Benji Jones

    The “zombie” fungus in The Last of Us, explained by a biologist

    A new HBO show, The Last of Us, is about a fungi-fueled apocalypse. Above, lead characters Joel (Pedro Pascal) and Tess (Anna Torv) discover a human body that was taken over by a fungus.
    A new HBO show, The Last of Us, is about a fungi-fueled apocalypse. Above, lead characters Joel (Pedro Pascal) and Tess (Anna Torv) discover a human body that was taken over by a fungus.
    A new HBO show, The Last of Us, is about a fungi-fueled apocalypse. Above, lead characters Joel (Pedro Pascal) and Tess (Anna Torv) discover a human body that was taken over by a fungus.
    Liane Hentscher/HBO

    The scariest shows and movies are often the ones rooted in reality — about psychopathic serial killers, late-night home invasions, and AI robot dolls. Zombie apocalypses typically don’t count.

    But a new show on HBO, called The Last of Us, presents a compelling case that perhaps there’s such a thing as a realistic zombie. Or realistic-ish. And it’s definitely scary.

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